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设计思路：

利用<mx:menuitem></mx:menuitem>中的enabled属性控制指定的菜单项是否可用。

由于需要动态设置，因此设置对应的全局变量与该属性进行绑定(即添加[Bindable]标签)

代码：<?xml version="1.0" encoding="utf-8"?> 
<mx:Application xmlns:mx="http://www.adobe.com/2006/mxml" 
                layout="absolute"> 
    <mx:Script> 
        <!--[CDATA[  
            [Bindable]  
            private var saveEnabledFlag:Boolean=true;  
 
            private function disableSave():void  
            {  
                saveEnabledFlag=false;  
            }  
 
            private function enableSave():void  
            {  
                saveEnabledFlag=true;  
            }  
        ]]--> 
    </mx:Script> 
    <mx:VBox width="100%" 
             height="100%" 
             horizontalAlign="center"> 
        <mx:MenuBar id="mainMenu" 
                    width="100%" 
                    labelField="@label"> 
            <mx:XMLList> 
                <menuitem label="Operation"> 
                    <mx:menuitem label="Find"/> 
                    <mx:menuitem label="Save" 
                                 enabled="{saveEnabledFlag}"/> 
                </menuitem> 
            </mx:XMLList> 
        </mx:MenuBar> 
        <mx:Button label="Disable Save" 
                   click="disableSave()"/> 
        <mx:Button label="Enable Save" 
                   click="enableSave()"/> 
    </mx:VBox> 
</mx:Application> 

演示效果：

Enable Status:

Disable Status: